Key result
Electric lumbar epidural blockade during labour resulted in a non-significant rise in plasma noradrenaline to 1.88 nmol/litre, whereas other pain relief led to a significant rise to 2.91 nmol/litre.
Why the study?
Does electric lumbar epidural blockade reduce plasma noradrenaline levels during labour compared to other forms of pain relief?
Cohort (n=20)
Does electric lumbar epidural blockade reduce plasma noradrenaline levels during labour compared to other forms of pain relief?
Absolute Event Rate: 1.88% vs 2.91%
p-value: p=<0.01
Electric lumbar epidural blockade may blunt the rise in plasma noradrenaline typically seen during the second stage of labour.
May blunt noradrenaline surge during labour; hypothesis-generating and should not yet change practice.
Plasma noradrenaline was assayed during augmented labour in nine patients receiving electric lumbar epidural blockade and in 11 patients using other forms of pain relief. Similar noradrenaline levels were seen in each group before induction of labour (epidural subjects 1.28; SEM 0.45 nmol/litre and non-epidural subjects 1.53; SEM 0.44 nmol/litre). At the onset of the second stage of labour the non-epidural patients showed a significant rise in plasma noradrenaline to 2.91; SEM 0.56 nmol/litre (p less than 0.01). The rise to 1.88; SEM 0.55 nmol/litre in the epidural group was not significant. Electric lumbar epidural block may influence plasma noradrenaline during labour.
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Falconer et al. (1982) conducted a cohort in Labour (n=20). Electric lumbar epidural blockade vs. Other forms of pain relief was evaluated on Plasma noradrenaline levels at the onset of the second stage of labour (p=<0.01). Electric lumbar epidural blockade during labour resulted in a non-significant rise in plasma noradrenaline to 1.88 nmol/litre, whereas other pain relief led to a significant rise to 2.91 nmol/litre.
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