Why the study?
Does the addition of epinephrine to bupivacaine for lumbar epidural anesthesia increase maternal plasma epinephrine and norepinephrine concentrations in parturients undergoing cesarean delivery?
Population
38 healthy parturients undergoing cesarean delivery
Comparison
Bupivacaine-epinephrine mixture for lumbar… vs Bupivacaine 0.5% for lumbar epidural anesthesia…
Design
RCT, randomly divided into two equal groups
Follow-up
50 minutes after delivery
Authors
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Supports caution with epinephrine-containing epidurals in cesarean delivery; confirms significant systemic absorption of epidural epinephrine.
Does the addition of epinephrine to bupivacaine for lumbar epidural anesthesia increase maternal plasma epinephrine and norepinephrine concentrations in parturients undergoing cesarean delivery?
Epinephrine is absorbed from the epidural space during lumbar epidural anesthesia, significantly raising maternal circulating epinephrine concentrations.
Ramanathan et al. (1995) studied this question.
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