October 1, 1990Acta Anaesthesiologica Scandinavica

The maternal hemodynamic effects of bupivacaine‐epinephrine mixture used for obstetrical anesthesia

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Why the study?

Does the addition of epinephrine to bupivacaine for epidural anesthesia alter maternal hemodynamics in term gravidas undergoing cesarean section?

Population

32 term gravidas undergoing elective cesarean section

Comparison

Bupivacaine-epinephrine mixture administered via… vs Plain bupivacaine administered via lumbar…

Design

Cohort

Follow-up

Until T4 sensory level achieved during anesthesia

Authors

GGGilbert J. GrantNew York University SRSivam RamanathanCedars-Sinai Medical Center HTHerman TurndorfRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Epinephrine addition may induce maternal vasodilation and hypotension; leaves open randomized confirmation of clinical impact in cesarean anesthesia.

Structured PICO

Does the addition of epinephrine to bupivacaine for epidural anesthesia alter maternal hemodynamics in term gravidas undergoing cesarean section?

Population

32 term gravidas undergoing elective cesarean section

Intervention

Bupivacaine (0.5%)-epinephrine (5 μg/ml) mixture administered via lumbar epidural in 5-ml increments to a T4 level following i.v. hydration with 2000 ml Ringer's lactate (n=16)

Comparator

Plain bupivacaine administered via lumbar epidural in 5-ml increments to a T4 level following i.v. hydration with 2000 ml Ringer's lactate (n=16)

Outcome

Hemodynamic changes (systolic, diastolic, mean pressures, systemic vascular resistance, cardiac output, stroke volume, heart rate) measured at T10 and T4 sensory levelssurrogate

Epidurally administered epinephrine with bupivacaine produces mainly beta-2 mediated vasodilatation, significantly decreasing blood pressure and systemic vascular resistance without altering cardiac output or heart rate.

Cite This Study

Grant et al. (1990) studied this question.

synapsesocial.com/papers/6a902478bcd42327600d2ab8 https://doi.org/10.1111/j.1399-6576.1990.tb03142.x

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October 1, 1990Acta Anaesthesiologica Scandinavica

The maternal hemodynamic effects of bupivacaine‐epinephrine mixture used for obstetrical anesthesia

View Full Paper

Ask AI

Bookmark

Why the study?

Does the addition of epinephrine to bupivacaine for epidural anesthesia alter maternal hemodynamics in term gravidas undergoing cesarean section?

Population

32 term gravidas undergoing elective cesarean section

Comparison

Bupivacaine-epinephrine mixture administered via… vs Plain bupivacaine administered via lumbar…

Design

Cohort

Follow-up

Until T4 sensory level achieved during anesthesia

Authors

GGGilbert J. GrantNew York University SRSivam RamanathanCedars-Sinai Medical Center HTHerman TurndorfRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Epinephrine addition may induce maternal vasodilation and hypotension; leaves open randomized confirmation of clinical impact in cesarean anesthesia.

Structured PICO

Does the addition of epinephrine to bupivacaine for epidural anesthesia alter maternal hemodynamics in term gravidas undergoing cesarean section?

Population

32 term gravidas undergoing elective cesarean section

Intervention

Bupivacaine (0.5%)-epinephrine (5 μg/ml) mixture administered via lumbar epidural in 5-ml increments to a T4 level following i.v. hydration with 2000 ml Ringer's lactate (n=16)

Comparator

Plain bupivacaine administered via lumbar epidural in 5-ml increments to a T4 level following i.v. hydration with 2000 ml Ringer's lactate (n=16)

Outcome

Hemodynamic changes (systolic, diastolic, mean pressures, systemic vascular resistance, cardiac output, stroke volume, heart rate) measured at T10 and T4 sensory levelssurrogate

Cite This Study

Grant et al. (1990) studied this question.

synapsesocial.com/papers/6a902478bcd42327600d2ab8 https://doi.org/10.1111/j.1399-6576.1990.tb03142.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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