Why the study?
Does intravenous epinephrine affect maternal hemodynamics and uterine blood flow in gravid ewes?
Population
10 chronically instrumented gravid ewes
Comparison
Epinephrine 5, 10, or 20 micrograms iv bolus… vs Bupivacaine 5 mg iv
Design
Preclinical
Follow-up
Acute (minutes)
Authors
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May caution epinephrine use in obstetric anesthesia; leaves open translation to human pregnancy.
Does intravenous epinephrine affect maternal hemodynamics and uterine blood flow in gravid ewes?
Small intravenous boluses of epinephrine significantly decrease uterine blood flow and transiently increase maternal mean arterial pressure in gravid ewes.
Hood et al. (1986) studied this question.
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