Why the study?
Does intravenous isoproterenol have a safer hemodynamic profile compared to epinephrine as a marker of accidental intravascular injection in a pregnant ewe model?
Population
Chronic maternal-fetal sheep preparation (pregnant ewe)
Comparison
Intravenous isoproterenol (five doses tested) vs Intravenous epinephrine (two doses tested)
Design
Preclinical, randomized cross-over fashion
Authors
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Isoproterenol may offer a safer profile than epinephrine for epidural test dosing; animal data leave open translation to human obstetric practice.
Does intravenous isoproterenol have a safer hemodynamic profile compared to epinephrine as a marker of accidental intravascular injection in a pregnant ewe model?
In a pregnant sheep model, isoproterenol demonstrated a more favorable hemodynamic profile than epinephrine, suggesting it may be a better alternative as an epidural test dose.
Marcus et al. (1996) studied this question.
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