Why the study?
Does intravenous isoproterenol alter maternal and fetal hemodynamics compared to saline in nonlaboring women at term?
Population
60 nonlaboring women at term (results of 50 used for analysis)
Comparison
Intravenous injection of 5 micrograms… vs Intravenous injection of 5 micrograms saline
Design
RCT, randomized, double-blind
Follow-up
10 minutes
Authors
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Supports isoproterenol as test dose for obstetric epidural analgesia; extends RCT hemodynamic data in term pregnancies.
Does intravenous isoproterenol alter maternal and fetal hemodynamics compared to saline in nonlaboring women at term?
Intravenous isoproterenol (5 micrograms) increases maternal heart rate and uterine blood flow without affecting umbilical blood flow, suggesting it may be a suitable test dose for epidural analgesia in obstetrics.
Marcus et al. (1997) studied this question.
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