Why the study?
Does an epidural test dose containing 3 micrograms isoproterenol reliably detect intravascular injection based on heart rate response in adult patients during isoflurane anesthesia?
Population
30 adult patients anesthetized with 1% end-tidal isoflurane and nitrous oxide after endotracheal intubation
Comparison
3 mL of 1.5% lidocaine with 3 micrograms… vs 3 mL of normal saline intravenously
Design
RCT, randomly assigned
Follow-up
4 minutes
Authors
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Supports isoproterenol test-dose use for intravascular detection during isoflurane anesthesia; extends RCT evidence to this setting.
Does an epidural test dose containing 3 micrograms isoproterenol reliably detect intravascular injection based on heart rate response in adult patients during isoflurane anesthesia?
An epidural test dose containing 3 micrograms isoproterenol is a highly sensitive and specific marker for detecting intravascular injection based on heart rate response in adults under isoflurane anesthesia.
Makoto Tanaka (1996) studied this question.
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