Why the study?
Does intravenous isoproterenol act as an effective marker of intravascular injection in anesthetized children?
Population
44 ASA 1 children, aged 2 months to 10 years, anesthetized with halothane and nitrous oxide in 50% oxygen.
Comparison
Isoproterenol 0.075 microgram/kg intravenous vs Isoproterenol 0.05 microgram/kg intravenous
Design
RCT, randomly assigned to two groups, blinded observer
Authors
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Isoproterenol 0.075 μg/kg reliably marks intravascular injection via heart rate rise in anesthetized children; extends adult data but needs pediatric safety confirmation.
Does intravenous isoproterenol act as an effective marker of intravascular injection in anesthetized children?
Isoproterenol 0.075 microgram/kg produces a reliable heart rate increase in anesthetized children, showing promise as an epidural test dose marker, though further safety evaluation is needed.
Perillo et al. (1993) studied this question.
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