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February 1, 1990AnesthesiologyOpen Access

Efficacy of an Epidural Test Dose in Children Anesthetized with Halothane

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Why the study?

Does atropine administration prior to an epinephrine-containing epidural test dose improve the reliable detection of intravascular injection in children anesthetized with halothane and nitrous oxide?

Population

65 children, 1 month to 11 years of age, weighing 3.9-35 kg, anesthetized with 1% halothane and 50% nitrous…

Comparison

Intravenous injection of 10 micrograms/kg… vs Simulated intravascular test dose of lidocaine…

Design

Other

Follow-up

120 seconds

Authors

JDJoëlle DesparmetMontreal Children's HospitalJMJoachim MateoHôpital LariboisièreCEClaude EcoffeyUniversité Paris-Sud

Discussion

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Implication

May warrant atropine pretreatment to improve epidural test-dose sensitivity in halothane-anesthetized children; leaves open confirmation in larger trials.

Structured PICO

Does atropine administration prior to an epinephrine-containing epidural test dose improve the reliable detection of intravascular injection in children anesthetized with halothane and nitrous oxide?

P
Population
65 children, 1 month to 11 years of age, weighing 3.9-35 kg, anesthetized with 1% halothane and 50% nitrous oxide.
I
Intervention
Intravenous injection of 10 micrograms/kg atropine followed 5 minutes later by an intravenous dose of 0.1 ml/kg 1% lidocaine with 1/200,000 epinephrine (0.5 micrograms/kg) to simulate an intravascularly administered epidural test dose.
C
Comparator
Simulated intravascular test dose of lidocaine with epinephrine without prior atropine, or test doses of lidocaine without epinephrine (with or without prior atropine).
O
Outcome
Reliably detectable increase in heart rate and systemic blood pressure.surrogate

Atropine improves the reliability of an epinephrine-containing epidural test dose in detecting intravascular injection in children anesthetized with halothane and nitrous oxide, though it does not ensure total reliability.

Cite This Study

Desparmet et al. (1990) studied this question.

synapsesocial.com/papers/6a8ada4bf8241cb45bfb3c6fhttps://doi.org/10.1097/00000542-199002000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Simulation of an Epidural Test Dose with Intravenous Epinephrine in Sevoflurane-Anesthetized Children1998 · 29 citations
  2. 2Efficacy of an Epidural Test Dose in Adult Patients Anesthetized with Isoflurane1995 · 23 citations
  3. 3Efficacy of an Epidural Test Dose in Adult Patients Anesthetized with Isoflurane1995
  4. 4Comparison of Isoprenaline with Adrenaline as Components of Epidural Test Dose Solutions for Halothane Anaesthetized Children2002 · 3 citations
  5. 5Intravenous Isoproterenol as a Marker for Epidural Test-Dosing in Children1993 · 54 citations