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February 1, 2002Anaesthesia and Intensive CareOpen Access

Comparison of Isoprenaline with Adrenaline as Components of Epidural Test Dose Solutions for Halothane Anaesthetized Children

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Why the study?

Does isoprenaline compared to adrenaline improve the reliability of detecting intravascular injection during epidural test dosing in halothane-anaesthetized children?

Population

Children anaesthetized with halothane

Comparison

Intravenous injection of lignocaine 1 mg/kg with… vs Intravenous injection of lignocaine 1 mg/kg with…

Design

RCT, randomized

Authors

ATAsha TyagiUniversity College of Medical SciencesASAnkur SethiRutgers, The State University of New JerseyCCC. ChatterjiUniversity College of Medical Sciences

Discussion

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Implication

Supports isoprenaline over adrenaline for reliable epidural test dosing; extends RCT evidence in children but leaves neurological safety open.

Structured PICO

Does isoprenaline compared to adrenaline improve the reliability of detecting intravascular injection during epidural test dosing in halothane-anaesthetized children?

P
Population
Children anaesthetized with halothane
I
Intervention
Intravenous injection of lignocaine 1 mg/kg with isoprenaline 0.05 microg/kg or 0.075 microg/kg
C
Comparator
Intravenous injection of lignocaine 1 mg/kg with no additive, or adrenaline 0.5 microg/kg
O
Outcome
Positive test response defined as an increase of >= 10 bpm in heart rate or >= 20% rise in blood pressuresurrogate

Isoprenaline is a more reliable marker than adrenaline for detecting intravascular injection during epidural test dosing in halothane-anaesthetized children, though its neurological safety requires confirmation.

Limitations

  • Safety of isoprenaline's effect on neurological tissue is not confirmed

Cite This Study

Tyagi et al. (2002) studied this question.

synapsesocial.com/papers/6a899672f8670bac6e334c68https://doi.org/10.1177/0310057x0203000105
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous Isoproterenol as a Marker for Epidural Test-Dosing in Children1993 · 54 citations
  2. 2Efficacy of an Epidural Test Dose in Children Anesthetized with Halothane1990 · 121 citations
  3. 3The Hemodynamic Responses to an Intravenous Test Dose in Vascular Surgical Patients1995 · 24 citations
  4. 4Epidural Test Dose and Intravascular Injection in Obstetrics1992 · 56 citations
  5. 5Isoproterenol is an Effective Marker of Intravenous Injection in Laboring Women1989 · 49 citations