Why the study?
Does an IV test dose of lidocaine with epinephrine reliably increase heart rate or systolic blood pressure to detect intravascular injection in adult patients anesthetized with isoflurane?
Population
30 adult patients anesthetized with 1% end-tidal isoflurane and nitrous oxide after endotracheal intubation
Comparison
3 mL of 1.5% lidocaine with epinephrine IV vs 3 mL of normal saline IV
Design
RCT, randomly assigned
Follow-up
4 minutes
Authors
Loading...
SBP >15 mm Hg should supplant HR for test-dose interpretation under isoflurane; extends validation of epinephrine criteria to anesthetized adults.
Does an IV test dose of lidocaine with epinephrine reliably increase heart rate or systolic blood pressure to detect intravascular injection in adult patients anesthetized with isoflurane?
Systolic blood pressure increases >15 mm Hg are a more reliable indicator than heart rate for detecting intravascular injection of an epinephrine-containing test dose in adults under isoflurane anesthesia.
Tanaka et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: