Key result
An intravenous test dose containing 15 μg of epinephrine reliably identified intravascular injection in vascular surgical patients, indicated by a heart rate increase of ≥9 bpm.
Why the study?
Does an intravenous test dose of lidocaine and epinephrine reliably identify intravascular injection by changing hemodynamic responses in vascular surgical patients?
Population
n=50 patients presenting for vascular surgery and requiring an arterial line, not receiving beta-adrenergic…
Comparison
3-mL intravenous injection of lidocaine 45 mg… vs 3-mL intravenous injection of saline or…
Design
RCT, randomly assigned, double-blind
Follow-up
3 minutes
Authors
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Validates 15 μg epinephrine test dose (≥9 bpm HR threshold) for intravascular detection in vascular surgery; extends prior evidence to this higher-risk population.
RCT (n=50)
Double-blind
randomly assigned
Does an intravenous test dose of lidocaine and epinephrine reliably identify intravascular injection by changing hemodynamic responses in vascular surgical patients?
A test dose containing 15 micrograms of epinephrine is reliable for identifying intravascular injection in vascular surgical patients, using a lower heart rate increase criterion (>= 9 bpm) than in healthier populations.
Schoenwald et al. (1995) conducted an RCT in Vascular surgery (n=50). Intravenous test dose of lidocaine 45 mg and epinephrine 15 micro gram vs. Saline, lidocaine 45 mg alone, or lidocaine 45 mg with 5 or 10 micro gram epinephrine was evaluated on Changes in heart rate (HR), systolic (SBP), mean (MBP), and diastolic (DBP) blood pressure. An intravenous test dose containing 15 μg of epinephrine reliably identified intravascular injection in vascular surgical patients, indicated by a heart rate increase of ≥9 bpm.
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