Why the study?
Does intravenous isoproterenol alter hemodynamic variables compared to saline in nonlaboring women at term?
Population
60 nonlaboring women at term (results of 50 women used for further analysis)
Comparison
Isoproterenol 5 micro g intravenous injection vs Saline 5 micro g intravenous injection
Design
RCT, randomized, double-blind
Follow-up
10 min
Authors
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Supports isoproterenol as epidural test dose in term parturients; extends RCT evidence for selective maternal hemodynamic effects.
Does intravenous isoproterenol alter hemodynamic variables compared to saline in nonlaboring women at term?
Intravenous isoproterenol (5 micro g) increases maternal heart rate and uterine blood flow without affecting umbilical blood flow, suggesting it may be a suitable test dose for epidural analgesia in obstetrics.
Marcus et al. (1997) studied this question.
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