Why the study?
Does intravenous isoproterenol compared to epinephrine have a safer hemodynamic profile in pregnant ewes?
Population
Pregnant ewes (chronic maternal-fetal sheep preparation)
Comparison
Intravenous isoproterenol (five doses tested) vs Intravenous epinephrine (two doses tested)
Design
Preclinical, randomized cross-over fashion
Authors
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Should not change epidural test-dose practice; leaves open whether isoproterenol offers a safer profile than epinephrine in human pregnancy.
Does intravenous isoproterenol compared to epinephrine have a safer hemodynamic profile in pregnant ewes?
Isoproterenol may be a safer alternative to epinephrine as a test dose for epidural catheter placement in pregnant women due to less pronounced effects on uterine blood flow.
Marcus et al. (1996) studied this question.
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