October 12, 2025Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control

Transdermal Fentanyl in Postoperative Pain

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Authors

LLLance J. LehmannBeth Israel Deaconess Medical Center JDJohn M. DeSioBeth Israel Deaconess Medical Center TRTibor RadvanyUniversity of Miami

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Implication

This placebo-controlled trial compares transdermal fentanyl with placebo for pain relief in postoperative patients, revealing its potential effectiveness.

Key Points

Transdermal fentanyl provided significant postoperative analgesia with lower requirements for additional analgesics.
Plasma fentanyl concentrations were measured at 12 and 24 hours, showing levels of 0.98 ng/mL and 1.22 ng/mL respectively.
Nausea occurred in 12 patients receiving fentanyl compared to 5 in the placebo group, indicating some gastrointestinal side effects.
The transdermal patch did not negatively affect respiratory rates or hemoglobin oxygen saturation during the study.

Cite This Study

Lehmann et al. (1997) studied this question.

synapsesocial.com/papers/68eb6f7ceea689731b3006b9 https://doi.org/10.1136/rapm-00115550-199722010-00004

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Implication

This placebo-controlled trial compares transdermal fentanyl with placebo for pain relief in postoperative patients, revealing its potential effectiveness.

Transdermal Fentanyl in Postoperative Pain

Discussion

Member takes

Implication

Key Points

Cite This Study

Transdermal Fentanyl in Postoperative Pain

Discussion

Member takes

Implication

Key Points

Cite This Study

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