Why the study?
Does the mode of intravenous fentanyl administration affect postoperative plasma fentanyl concentrations and clinical outcomes in patients undergoing major abdominal gynaecological surgery?
Population
30 patients undergoing major abdominal gynaecological surgery
Comparison
Fentanyl given as a loading dose of 10 µg/kg… vs Fentanyl given as a loading dose of 10 µg/kg…
Design
Cohort
Follow-up
first 3 h after operation
Authors
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Secondary peaks most frequent with infusions may raise hypoxemia risk; leaves open optimal mode for major gynaecological surgery.
Does the mode of intravenous fentanyl administration affect postoperative plasma fentanyl concentrations and clinical outcomes in patients undergoing major abdominal gynaecological surgery?
Different modes of intravenous fentanyl administration result in varying rates of secondary plasma fentanyl peaks and postoperative analgesia requirements, highlighting the risk of additive effects and arterial hypoxaemia.
McQuay et al. (1980) studied this question.
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