Why the study?
Does fentanyl with or without naloxone alter plasma AVP and cortisol levels compared to halothane in normal patients undergoing gynecologic laparotomies?
Population
35 normal patients undergoing gynecologic laparotomies
Comparison
Nitrous oxide-oxygen plus small doses of… vs Nitrous oxide-oxygen plus halothane (n=13)
Design
Cohort
Follow-up
during surgery
Authors
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Fentanyl induction may increase AVP release in surgical patients; leaves open whether this alters outcomes or supports naloxone coadministration.
Does fentanyl with or without naloxone alter plasma AVP and cortisol levels compared to halothane in normal patients undergoing gynecologic laparotomies?
Small doses of fentanyl during anesthesia induction may cause AVP release, which can be prevented by naloxone.
Lehtinen et al. (1984) studied this question.
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