Why the study?
Does very high-dose fentanyl infusion compared to a single high dose improve hemodynamic stability in patients undergoing coronary artery surgery?
Population
20 patients undergoing coronary artery surgery
Comparison
Fentanyl 75-micrograms/kg intravenous dose… vs Fentanyl single 75-micrograms/kg intravenous dose
Design
RCT, Randomly selected into two groups
Follow-up
Postoperative ventilation period (approx 16-19 hours)
Authors
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Continuous fentanyl infusion may enhance CPB stability in CABG; extends RCT evidence on high-dose opioid strategies.
Does very high-dose fentanyl infusion compared to a single high dose improve hemodynamic stability in patients undergoing coronary artery surgery?
Very high-dose fentanyl infusion reduces the incidence of hypertension during cardiopulmonary bypass compared to a single high dose, though it does not completely suppress hypertensive responses.
Wynands et al. (1983) studied this question.
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