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September 1, 1981AnesthesiologyOpen Access

Hemodynamic Changes during Fentanyl—Oxygen Anesthesia for Aortocoronary Bypass Operation

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Why the study?

Does fentanyl/O2/relaxant anesthesia prevent hemodynamic responses to noxious stimulation in patients undergoing aortocoronary bypass?

Population

12 patients with coronary artery disease undergoing elective aortocoronary bypass with left ventricular…

Comparison

Fentanyl/O2/relaxant anesthesia. vs Baseline measurements and sequential…

Design

Cohort

Follow-up

Intraoperative

Authors

JWJohn L. WallerAugusta UniversityCHCarl C. HugUniversidad MayorDNDavid NagleEmory University

Discussion

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Implication

High-dose fentanyl may fail to blunt hemodynamic responses in CABG; leaves open optimal anesthesia strategies for myocardial oxygen balance.

Structured PICO

Does fentanyl/O2/relaxant anesthesia prevent hemodynamic responses to noxious stimulation in patients undergoing aortocoronary bypass?

P
Population
12 patients with coronary artery disease (CAD) undergoing elective aortocoronary bypass (ACB) with left ventricular (LV) ejection fractions > 0.4, maintained on propranolol until 10 hours before operation and premedicated with fentanyl, diazepam, and scopolamine.
I
Intervention
Fentanyl/O2/relaxant anesthesia (fentanyl 62.4 +/- 2.9 microgram/kg, 100% oxygen, pancuronium 0.1 mg/kg, succinylcholine).
C
Comparator
Baseline measurements (breathing oxygen) and sequential measurements after each intervention step.
O
Outcome
Hemodynamic changes (intravascular pressures, arterial blood gases, and thermodilution cardiac output) in response to noxious stimulation (intubation, skin incision, and sternotomy).surrogate

High-dose fentanyl-oxygen anesthesia fails to block hemodynamic responses to noxious surgical stimulation during aortocoronary bypass, potentially unfavorably affecting myocardial oxygen balance.

Cite This Study

Waller et al. (1981) studied this question.

synapsesocial.com/papers/6a82daf1040bdabcf347037ehttps://doi.org/10.1097/00000542-198109000-00005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Blood Flow and Oxygen Consumption during High-dose Fentanyl Anesthesia in Patients with Coronary Artery Disease1982 · 109 citations
  2. 2Oxygen-Fentanyl Anesthesia in Patients with Poor Left Ventricular Function1983 · 24 citations
  3. 3Oxygen-High Dose Fentanyl-Droperidol Anesthesia for Aortocoronary Bypass Surgery1981 · 10 citations
  4. 4Oxygen-High Dose Fentanyl-Droperidol Anesthesia for Aortocoronary Bypass Surgery1982 · 16 citations
  5. 5Cardiovascular Effects of and Catecholamine Responses to High Dose Fentanyl-O2 for Induction of Anesthesia in Patients with Ischemic Coronary Artery Disease1981 · 44 citations