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June 1, 1982AnesthesiologyOpen Access

Myocardial Blood Flow and Oxygen Consumption during High-dose Fentanyl Anesthesia in Patients with Coronary Artery Disease

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Why the study?

Does high-dose fentanyl anesthesia protect the myocardium from ischemia during coronary artery surgery in patients on beta-blockers?

Population

9 patients with coronary artery disease undergoing three-vessel coronary artery bypass operations, on…

Comparison

Fentanyl-oxygen anesthesia at moderate and high… vs Awake state (baseline measurements).

Design

Case_series

Follow-up

During surgery (up to sternotomy)

Authors

HSH. SonntagUniversity of GöttingenRLReinhard LarsenOsnabrück UniversityOHOtto Hiifiker

Discussion

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Implication

High-dose fentanyl may not prevent ischemia at sternotomy in beta-blocked CAD patients; this Level 5 case series leaves optimal regimens unresolved.

Structured PICO

Does high-dose fentanyl anesthesia protect the myocardium from ischemia during coronary artery surgery in patients on beta-blockers?

P
Population
9 patients with coronary artery disease undergoing three-vessel coronary artery bypass operations, on maintenance doses of a beta-receptor blocker (pindolol).
I
Intervention
Fentanyl-oxygen anesthesia at moderate (10 micrograms/kg) and high (100 micrograms/kg) doses.
C
Comparator
Awake state (baseline measurements).
O
Outcome
Myocardial blood flow, myocardial oxygen consumption, myocardial lactate balance, and cardiovascular dynamics.surrogate

High-dose fentanyl as a sole anesthetic fails to protect the myocardium from ischemia during sternotomy in patients with coronary artery disease on beta-blockers.

Cite This Study

Sonntag et al. (1982) studied this question.

synapsesocial.com/papers/6a82daf1040bdabcf347037dhttps://doi.org/10.1097/00000542-198206000-00001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic Changes during Fentanyl—Oxygen Anesthesia for Aortocoronary Bypass Operation1981 · 117 citations
  2. 2Cardiovascular Effects of and Catecholamine Responses to High Dose Fentanyl-O2 for Induction of Anesthesia in Patients with Ischemic Coronary Artery Disease1981 · 44 citations
  3. 3Effect of Fentanyl on Myocardial Metabolism during Ischemia1982 · 5 citations
  4. 4Comparison of Hemodynamic and Hormonal Effects of Large Single-Dose Fentanyl Anesthesia and Halothane/Nitrous Oxide Anesthesia for Coronary Artery Surgery1982 · 35 citations
  5. 5Muscle relaxants change myocardial metabolism in patients with ischemic heart disease during high‐dose fentanyl anesthesia1990 · 8 citations