Why the study?
Does fentanyl improve myocardial metabolism during ischemia in a canine model?
Population
Dogs in open-chest experiments with ischemia induced by partial occlusion of a coronary artery
Comparison
Fentanyl injected IV 5 minutes before induction… vs The animal as its own control
Design
Preclinical
Authors
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Does not support fentanyl use in human ischemia; leaves open translation of canine metabolic effects to clinical practice.
Does fentanyl improve myocardial metabolism during ischemia in a canine model?
Fentanyl reduces myocardial oxygen demand and improves metabolic parameters during acute ischemia in a canine model, suggesting potential benefits during anesthesia for patients with coronary artery disease.
Reneman et al. (1982) studied this question.
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