Why the study?
Different intraoperative analgesic strategies may impact hyperalgesia and subsequent chronic post-sternotomy pain after CABG, but the effect of different fentanyl dosing regimens was unclear.
Does the intraoperative dosing regimen of fentanyl influence the area of hyperalgesia and postoperative pain in patients undergoing elective on-pump CABG?
Population
66 patients undergoing elective on-pump CABG
Comparison
High fentanyl regimen vs low fentanyl regimen vs Shibutani continuous dosing regimen
Design
Prospective, randomized double-blind clinical trial
Follow-up
12 months
Authors
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Lower fentanyl doses increased short-term pain without reducing hyperalgesia; challenges opioid-sparing approaches in CABG and leaves optimal regimens open.
Does the intraoperative dosing regimen of fentanyl influence the area of hyperalgesia and postoperative pain in patients undergoing elective on-pump CABG?
Different intraoperative fentanyl dosing regimens during on-pump CABG do not significantly affect postoperative hyperalgesia, but lower doses may result in more short-term pain.
Slagmulder et al. (2022) studied this question.
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