What does this research mean for the field?

Transdermal buprenorphine and fentanyl patches provide more effective postoperative analgesia and improved quality of recovery compared to standard intravenous analgesia following inguinal hernia surgery, with buprenorphine showing an early advantage in recovery quality over fentanyl. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the effects of preoperative transdermal buprenorphine and fentanyl patches versus conventional intravenous analgesia on pain control and quality of recovery following open inguinal hernia repair.

August 23, 2026Anesthesia and Pain MedicineOpen Access

An evaluation of transdermal buprenorphine and transdermal fentanyl patch on quality of recovery-15 and analgesic effect following inguinal hernia surgery: a randomized controlled study

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Authors

APA Chaitanya PratyushaAll India Institute of Medical Sciences GRG. RamachandranAll India Institute of Medical Sciences SGSandeep GarreBirla Institute of Technology and Science - Hyderabad Campus

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Implication

Randomized trial demonstrates transdermal buprenorphine and fentanyl patches enhance pain relief and quality of recovery after inguinal hernia surgery, indicating their clinical value.

Key Points

To compare the effects of preoperative transdermal buprenorphine and fentanyl patches versus conventional intravenous analgesia on pain control and quality of recovery following open inguinal hernia repair.
Prospective randomized trial including 150 ASA I–III patients undergoing elective open inguinal hernia repair, allocated equally (n=50 each) to buprenorphine (10 μg/h patch), fentanyl (25 μg/h patch), or control (intravenous paracetamol and tramadol).
Patches were placed 12 hours before surgery; primary outcome was visual analog scale (VAS) pain scores across 24 hours, and secondary outcomes included QoR-15 scores at 24 and 48 hours.
Postoperative VAS pain scores at 6, 12, and 24 hours were significantly lower in both transdermal patch groups compared to the intravenous control group.
Median QoR-15 scores at 24 hours were 124 (122–125) for control, 127 (125–129) for fentanyl, and 133 (131–134) for buprenorphine; at 48 hours, scores were 129 (128–130), 136 (134–138), and 137 (135–139), respectively (P = 0.001).

Cite This Study

Pratyusha et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadb47677a3411444607b https://doi.org/10.17085/apm.25462

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Implication

Randomized trial demonstrates transdermal buprenorphine and fentanyl patches enhance pain relief and quality of recovery after inguinal hernia surgery, indicating their clinical value.

An evaluation of transdermal buprenorphine and transdermal fentanyl patch on quality of recovery-15 and analgesic effect following inguinal hernia surgery: a randomized controlled study

Discussion

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Implication

Key Points

Cite This Study

An evaluation of transdermal buprenorphine and transdermal fentanyl patch on quality of recovery-15 and analgesic effect following inguinal hernia surgery: a randomized controlled study

Discussion

Member takes

Implication

Key Points

Cite This Study

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