Comparative Study of Subarachnoid Fentanyl and Buprenorphine Added with Bupivacaine for Postoperative Analgesia in Lower Limb and Lower Abdominal Surgeries

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Observational analysis shows buprenorphine offers longer analgesia than fentanyl in postoperative patients, suggesting enhanced recovery.

The duration of analgesia from buprenorphine administration is statistically longer than from fentanyl.
Postoperative analgesia with buprenorphine lasted an average of 14.02 hours, compared to 10.72 hours for fentanyl.
Intrathecal administration of both fentanyl and buprenorphine significantly exceeds the control group of bupivacaine alone.
Both medications showed side effects, but buprenorphine had more reports of pruritis among patients.

Kocheta et al. (2025) studied this question.

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