Key result
The addition of 1mcg/kg fentanyl to 0.125% bupivacaine significantly prolonged the time to first rescue analgesia compared to bupivacaine alone (285.55 vs 103.56 minutes, p=0.003) in patients undergoing abdominal surgeries.
Why the study?
Selecting drugs for epidural anaesthesia requires understanding anaesthetic potency and postoperative analgesia requirements, motivating an evaluation of bupivacaine alone versus bupivacaine with fentanyl in abdominal surgery.
Does the addition of fentanyl to bupivacaine improve postoperative analgesia in adults undergoing abdominal surgeries?
Population
100 adults aged 18-60 years with ASA grade I and II undergoing abdominal surgeries under general anesthesia
Comparison
0.125% bupivacaine with 1mcg/kg fentanyl vs 0.125% bupivacaine alone
Design
Randomized study
Authors
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Supports fentanyl addition to epidural bupivacaine for prolonged postoperative analgesia; confirms RCT benefit but cautions on nausea, vomiting, and pruritus.
RCT (n=100)
Randomly divided
No
Does the addition of fentanyl to bupivacaine improve postoperative analgesia in adults undergoing abdominal surgeries?
Absolute Event Rate: 285.55% vs 103.56%
p-value: p=0.003
The addition of fentanyl to epidural bupivacaine significantly prolongs postoperative analgesia but is associated with a high incidence of nausea, vomiting, and pruritus.
CR Murali Govardhan (2020) conducted an RCT in Abdominal surgeries (n=100). Bupivacaine with fentanyl vs. 0.125% Bupivacaine alone was evaluated on Time for first rescue analgesia (minutes) (p=0.003). The addition of 1mcg/kg fentanyl to 0.125% bupivacaine significantly prolonged the time to first rescue analgesia compared to bupivacaine alone (285.55 vs 103.56 minutes, p=0.003) in patients undergoing abdominal surgeries.
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