Key result
Epidural fentanyl hastens sensory block onset by ~5 minutes vs bupivacaine alone, while buprenorphine prolongs analgesia.
Why the study?
Does the addition of fentanyl or buprenorphine to epidural bupivacaine improve analgesia in patients undergoing lower abdominal surgeries?
Population
75 ASA grade I and II patients between 20-50 years undergoing elective lower abdominal surgery under…
Comparison
Epidural buprenorphine or fentanyl added to… vs Epidural bupivacaine 0.5% 20ml alone
Design
RCT, randomly divided into 3 groups
Authors
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Supports fentanyl preference for faster onset in lower abdominal surgery; extends RCT comparisons of epidural opioid adjuvants.
RCT (n=75)
Investigator-blinded
Computer generated randomisation chart
No
Does the addition of fentanyl or buprenorphine to epidural bupivacaine improve analgesia in patients undergoing lower abdominal surgeries?
Absolute Event Rate: 9.53% vs 14.5%
p-value: p=<0.05
Fentanyl is a better adjuvant to epidural bupivacaine than buprenorphine for lower abdominal surgeries due to faster onset and fewer side effects.
Dr Shibani Padhy M.B.B.S (2016) conducted an RCT in Elective lower abdominal surgery (n=75). Epidural fentanyl or buprenorphine vs. 20 ml 0.5% bupivacaine alone was evaluated on Onset of sensory block (p=<0.05). Epidural fentanyl significantly hastened the onset of sensory block (9.53 minutes) compared to bupivacaine alone (14.5 minutes), while buprenorphine significantly prolonged the duration of analgesia (586 minutes).
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