Key result
Intrathecal clonidine extends analgesia by ~157 minutes versus fentanyl as a bupivacaine adjuvant.
Why the study?
Does intrathecal clonidine, buprenorphine, or fentanyl improve block characteristics and analgesia when added to bupivacaine in patients undergoing lower abdominal surgeries?
RCT (n=90)
Not explicitly stated
Computer random number sequence
No
Does intrathecal clonidine, buprenorphine, or fentanyl improve block characteristics and analgesia when added to bupivacaine in patients undergoing lower abdominal surgeries?
Absolute Event Rate: 353.19% vs 195.83%
p-value: p=<0.001
Intrathecal clonidine 50μg is an effective adjuvant to bupivacaine for prolonging sensory and motor block and analgesia in lower abdominal surgeries, though it causes mild sedation and haemodynamic variations.
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Intrathecal clonidine warrants consideration as preferred adjuvant for lower abdominal surgery; confirms RCT superiority over fentanyl and buprenorphine for analgesia duration.
Srinivasagam et al. (2016) conducted an RCT in Lower abdominal surgeries (n=90). Clonidine vs. Fentanyl (25μg) or Buprenorphine (75μg) was evaluated on Duration of analgesia (minutes) (p=<0.001). Intrathecal clonidine significantly prolonged duration of analgesia (353.2 min) compared to fentanyl (195.8 min) and buprenorphine (294.0 min) as an adjuvant to bupivacaine.
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