Key result
Intrathecal clonidine extends bupivacaine analgesia to ~353 minutes, beating fentanyl and buprenorphine.
Why the study?
Does intrathecal clonidine compared to fentanyl or buprenorphine prolong sensory and motor block and analgesia in patients undergoing lower abdominal and lower limb surgeries?
RCT (n=90)
Blinded (drug prepared by independent anesthesiologist)
Computer random number sequence
No
Does intrathecal clonidine compared to fentanyl or buprenorphine prolong sensory and motor block and analgesia in patients undergoing lower abdominal and lower limb surgeries?
Absolute Event Rate: 353.19% vs 195.83%
p-value: p=<0.001
Intrathecal clonidine 50μg is an effective adjuvant to hyperbaric bupivacaine, prolonging sensory and motor block and analgesia compared to fentanyl or buprenorphine, despite mild sedation and haemodynamic variations.
No takes yet. Share an insight, caveat, or question.
Supports intrathecal clonidine over fentanyl or buprenorphine for extended analgesia in lower abdominal/limb surgery; extends RCT evidence on spinal adjuvants.
Pal et al. (2015) conducted an RCT in Lower abdominal and lower limb surgeries (n=90). Clonidine vs. Fentanyl (25μg) and Buprenorphine (75μg) was evaluated on Duration of analgesia (minutes) (p=<0.001). Intrathecal clonidine significantly prolonged the duration of analgesia (353.19 min) compared to fentanyl (195.83 min) and buprenorphine (294.00 min) as an adjuvant to bupivacaine.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: