Evaluating clonidine and buprenorphine as adjuvants to intrathecal 0.5% hyperbaric bupivacaine in lower limb surgeries

Intrathecal clonidine and buprenorphine as adjuvants to 0.5 percent hyperbaric bupivacaine in lower limb surgery is of interest. Patients were randomly allocated to three control groups, each comprising 30 individuals. The analgesic duration was greatest in Group Bu (buprenorphine 280 +/- 20 min) compared to Group C (clonidine 250 +/- 25 min) and Group B (control 180 +/- 22 min). The clonidine group had increased sedation. Buprenorphine showed reduced damage and minor adverse effects.