Key result
Intrathecal clonidine added to bupivacaine delays first rescue analgesia by ~98 minutes.
Why the study?
Clonidine enhances the effectiveness of local anaesthetics, motivating examination of the effect of adding intrathecal clonidine to hyperbaric bupivacaine on postoperative pain relief and side effects in patients undergoing lower abdominal surgery.
Does intrathecal clonidine added to hyperbaric bupivacaine prolong postoperative analgesia in patients undergoing lower abdominal surgery?
RCT (n=80)
Randomly assigned
Yes
Does intrathecal clonidine added to hyperbaric bupivacaine prolong postoperative analgesia in patients undergoing lower abdominal surgery?
The addition of 60 mcg intrathecal clonidine to hyperbaric bupivacaine significantly prolongs the duration of postoperative analgesia but increases the incidence of bradycardia in patients undergoing lower abdominal surgery.
Supports adding intrathecal clonidine for extended analgesia after lower abdominal surgery; extends RCT evidence on spinal adjuvants.
Background: Clonidine is an alpha-2 adrenergic agonist with various actions, one of which enhances theeffectiveness of local anaesthetics. For patients undergoing lower abdominal surgery, we examined the effectof adding intrathecal clonidine to hyperbaric bupivacaine on postoperative pain relief and side effects, if any.Aim: To assess the efficacy of intrathecal clonidine along with hyperbaric Bupivacaine in patients undergoinglower abdominal surgeries.Method: It was a retrospective study carried out under spinal anaesthesia on 80 patients undergoing lowerabdominal surgery. The research population was assigned randomly to two groups; group B- received 15 mgbupivacaine+ 0.4mi Normal Saline and group C received 15 mg bupivacaine + 60mcg clonidine.Results: Addition of 60mcgs of intrathecal clonidine to 0.5% hyperbaric bupivacaine significantly prolongedthe duration of motor & sensory blockade along with the duration of effective postoperative analgesia. Thedemand for rescue analgesic was earlier in group B as compared to group C. Both groups were matched forthe side-effects like hypotension, bradycardia, nausea, vomiting, and shivering
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Priyanka Deshmukh (2020) conducted an RCT in Lower abdominal surgery (n=80). Intrathecal clonidine + hyperbaric bupivacaine vs. 15 mg bupivacaine + 0.4 ml normal saline was evaluated on Time for first rescue analgesia (minutes) (p=0.000). Intrathecal clonidine (60 mcg) added to hyperbaric bupivacaine significantly prolonged the mean time to first rescue analgesia to 357 minutes compared to 259.5 minutes with bupivacaine alone.
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