Key result
Epidural clonidine added to bupivacaine extends analgesia by ~244 minutes versus bupivacaine alone.
Why the study?
Acute pain leads to adverse physiological and psychological disturbances, prompting evaluation of the onset and duration of sensory anesthesia, motor paralysis, and analgesia using clonidine with bupivacaine.
Does epidural clonidine added to bupivacaine prolong the duration of analgesia in patients undergoing lower abdominal and lower limb surgeries?
Population
62 patients aged 18 to 60 years undergoing elective lower abdominal, gynaecological, and lower limb surgeries
Comparison
0.5% plain bupivacaine with clonidine (2μg/kg) vs bupivacaine alone
Design
Randomised controlled study
Authors
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Supports adding epidural clonidine to bupivacaine for prolonged analgesia in lower abdominal and limb surgeries; extends evidence for its use as a regional anesthetic adjuvant.
RCT (n=62)
Sealed envelope method
No
Does epidural clonidine added to bupivacaine prolong the duration of analgesia in patients undergoing lower abdominal and lower limb surgeries?
Absolute Event Rate: 380% vs 136%
p-value: p=<0.001
Adding clonidine to epidural bupivacaine safely prolongs analgesia and motor blockade in lower abdominal and limb surgeries, though it causes mild sedation and hemodynamic changes.
Arora et al. (2020) conducted an RCT in Elective lower abdominal, gynaecological and lower limb surgeries (n=62). Epidural Clonidine vs. 0.5% bupivacaine + 0.9% normal saline was evaluated on Duration of analgesia (minutes) (p=<0.001). Epidural clonidine (2μg/kg) added to bupivacaine significantly prolonged the duration of analgesia to 380 minutes compared to 136 minutes with bupivacaine alone in patients undergoing lower abdominal and lower limb surgeries.
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