Effect of Trimethoprim-sulphamethoxazole on Typhoid and Salmonella Carriers

Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers, one of whom has been a chronic carrier for 24 years.