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Serum glycoproteins are increased in mice bearing transplantable tumors. Water soluble glycoproteins are increased in the connective tissue bordering and abutting on the tumor. These findings support the thesis that increased circulating glycoproteins arise from the ground substance of the connective tissue at the site of invasive growth by a process of depolymerization, whereby smaller, water soluble and diffusible glycoprotein moieties are produced.
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H. R. Catchpole (1950) studied this question.
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