Key result
Incident viral or idiopathic pericarditis linked to ~31% higher 5-year mortality versus matched controls.
Why the study?
Viral or idiopathic pericarditis is often considered benign, although prior studies suggested associations with cardiovascular and noncardiovascular diseases such as malignancy.
Does incident viral or idiopathic pericarditis increase 5-year mortality and morbidity compared to the general population?
Population
7,988 patients discharged with first-time pericarditis and 79,880 matched controls in Denmark
Comparison
Patients with incident viral or idiopathic pericarditis vs matched general population controls
Design
Nationwide registry-based matched cohort study
Follow-up
5-year
Authors
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May inform post-discharge risk stratification in pericarditis; hypothesis-generating and requires prospective validation.
Cohort (n=87,868)
Yes
Does incident viral or idiopathic pericarditis increase 5-year mortality and morbidity compared to the general population?
Hazard Ratio: 1.31 (95% CI 1.13–1.52)
Absolute Event Rate: 92.9% vs 95.8%
Incident viral or idiopathic pericarditis is associated with a significantly higher 5-year mortality risk and increased hospital admissions compared to the general population, suggesting it is not always a benign condition.
Sigvardt et al. (2020) conducted a cohort in Incident viral or idiopathic pericarditis (n=87,868). Incident viral or idiopathic pericarditis vs. Matched individuals from the general population was evaluated on 5-year mortality (HR 1.31, 95% CI 1.13 to 1.52). Incident viral or idiopathic pericarditis was associated with higher 5-year mortality compared to matched controls (survival 92.9% vs 95.8%; adjusted HR 1.31; 95% CI 1.13-1.52).