Key result
Mitral valve replacement for Libman-Sacks endocarditis resulted in sudden, severe prosthetic valve dysfunction at one year due to disease progression despite immunosuppression.
Libman-Sacks endocarditis can progress and cause severe dysfunction of a prosthetic mitral valve despite maintenance immunosuppressive therapy.
Rapid prosthetic mitral valve failure can occur despite immunosuppression in Libman-Sacks endocarditis; leaves open optimal post-replacement therapy and surveillance.
A women who developed mitral stenosis from Libman-Sacks endocarditis is described. The mitral valve was replaced by a Starr-Edwards prosthesis. One year later, despite her being maintained on steroids and azathioprine, the verrucous endocarditis progressed to cause sudden, severe dysfunction of the prosthetic valve.
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Vaughton et al. (1979) studied this question. Mitral valve replacement for Libman-Sacks endocarditis resulted in sudden, severe prosthetic valve dysfunction at one year due to disease progression despite immunosuppression.
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