The presence of lupus anticoagulant and anticardiolipin antibodies in Degos' disease suggests a potential aetiological link and therapeutic target for this fatal thrombotic vasculopathy.
Antiphospholipid antibodies may link to Degos' vasculopathy; this case leaves open whether testing or therapy alters outcomes.
A woman presented with multiple cerebral thromboses and skin lesions characteristic of Degos' disease. Her serum contained high titres of anticardiolipin antibodies and showed lupus anticoagulant activity, both known to be strong markers of a thrombotic tendency in systemic lupus erythematosus. This finding may have therapeutic implications for this usually fatal disease.
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Englert et al. (1984) studied this question.
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