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September 1, 2026Trends in ParasitologyOpen Access

New insights on Plasmodium gene expression from direct RNA sequencing

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Authors

JGJanne GrünebastDSDavid Serre

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Overview

Review highlights advances in native transcriptomic profiling in Plasmodium parasites, suggesting broader roles for post-transcriptional regulation across life stages.

Key Points

  • Summarize the applications, advantages, and limitations of Oxford Nanopore direct RNA sequencing for investigating gene expression and post-transcriptional mechanisms in Plasmodium parasites.
  • Evaluated direct RNA sequencing via Oxford Nanopore Technology (ONT) for analyzing native, full-length RNA molecules without reverse transcription to cDNA.
  • Synthesized findings regarding parasite isoform diversity, alternative splicing, non-coding RNAs, RNA modifications, and poly(A) tail dynamics.
  • Direct RNA sequencing captures full-length transcripts across entire genes, resolving untranslated regions, novel isoforms, and alternative splicing patterns in Plasmodium.
  • Native RNA profiling reveals complex poly(A) tail dynamics and epitranscriptomic modifications, uncovering post-transcriptional regulation mechanisms beyond standard translational repression in gametocytes and sporozoites.

Cite This Study

Grünebast et al. (2026) studied this question.

synapsesocial.com/papers/6a9e2fe40bfbee156fd6f0fbhttps://doi.org/10.1016/j.pt.2026.08.006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of an Oxford nanopore sequencing technology-based whole genome sequencing method for Plasmodium falciparum to support malaria molecular surveillance2026
  2. 2Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax transcripts2022
  3. 3Novel single-cell preservation and RNA sequencing technology unlocks field studies for<i>Plasmodium</i>natural infections2024
  4. 4Nanopore direct RNA sequencing for RNA modification analysis: workflow assessment and computational tool benchmarking2026 · 1 citations
  5. 5Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing2025 · 6 citations