Key result
Remote imaging photoplethysmography responses to autonomic nervous stimuli correlated significantly with laser speckle imaging measures of cutaneous perfusion (r = 0.62, p < 0.001).
Why the study?
It was unknown whether remote imaging photoplethysmography (iPPG) is sufficiently sensitive to monitor cutaneous perfusion.
Is remote imaging photoplethysmography (iPPG) sufficiently sensitive to monitor cutaneous perfusion compared to Laser speckle imaging (LSI) in volunteers?
Observational (n=37)
No
Is remote imaging photoplethysmography (iPPG) sufficiently sensitive to monitor cutaneous perfusion compared to Laser speckle imaging (LSI) in volunteers?
Effect estimate: r = 0.62
p-value: p=<0.001
Remote imaging photoplethysmography is sensitive to autonomic nervous activity and closely correlates with cutaneous perfusion in volunteers.
May support non-contact perfusion monitoring in research; leaves open prospective validation before clinical use.
Remote imaging photoplethysmography (iPPG) senses the cardiac pulse in outer skin layers and is responsive to mean arterial pressure and pulse pressure in critically ill patients. Whether iPPG is sufficiently sensitive to monitor cutaneous perfusion is not known. This study aimed at determining the response of iPPG to changes in cutaneous perfusion measured by Laser speckle imaging (LSI). Thirty-seven volunteers were engaged in a cognitive test known to evoke autonomic nervous activity and a Heat test. Simultaneous measurements of iPPG and LSI were taken at baseline and during cutaneous perfusion challenges. A perfusion index (PI) was calculated to assess iPPG signal strength. The response of iPPG to the challenges and its relation to LSI were determined. PI of iPPG significantly increased in response to autonomic nervous stimuli and to the Heat test by 5.8% (p = 0.005) and 11.1% (p < 0.001), respectively. PI was associated with LSI measures of cutaneous perfusion throughout experiments (p < 0.001). iPPG responses to study task correlated with those of LSI (r = 0.62, p < 0.001) and were comparable among subjects. iPPG is sensitive to autonomic nervous activity in volunteers and is closely associated with cutaneous perfusion.
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Rasche et al. (2020) conducted an observational in Healthy volunteers (n=37). Cognitive and heat tests vs. Baseline was evaluated on Correlation between iPPG perfusion index response and LSI cutaneous perfusion response (r = 0.62, p=<0.001). Remote imaging photoplethysmography responses to autonomic nervous stimuli correlated significantly with laser speckle imaging measures of cutaneous perfusion (r = 0.62, p < 0.001).
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