Key result
A high-speed atomic force microscope developed at Kanazawa University enables the imaging of biological macromolecules and motor proteins in action at nanometer resolution.
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The development of a high-speed atomic force microscope allows for the real-time imaging of biological macromolecules, such as motor proteins, in action.
The atomic force microscope (AFM), which was invented by Binnig et al. in 1986, can image at nanometer resolution individual biological macromolecules on a substrate in solution. This unique capability awoke an expectation of imaging processes occurring in biological macromolecules at work. However, this expectation was not met, because the imaging rate with available AFMs was too low to capture biological processes. This expectation has at last been realized by the high-speed AFM developed by our research group at Kanazawa University. In this article, after a brief review of the development of our apparatus, its recent advancement and imaging data obtained with motor proteins are presented.
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Ando et al. (2003) reported a review. High-speed atomic force microscope (AFM) was evaluated. A high-speed atomic force microscope developed at Kanazawa University enables the imaging of biological macromolecules and motor proteins in action at nanometer resolution.
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