Key result
Congenital heart disease was associated with significantly elevated serum levels of TNF-α (mean 100.69 vs 24.09) and IL-6 compared to healthy controls (p<0.001).
Why the study?
Do serum levels of TNF-α and IL-6 differ between children with congenital heart disease and healthy controls?
Case-Control (n=90)
No
Do serum levels of TNF-α and IL-6 differ between children with congenital heart disease and healthy controls?
Answers are grounded in this paper and cite their sources.
Serum levels of TNF-α and IL-6 are significantly elevated in children with congenital heart disease compared to healthy controls, which may be related to hypoxia and contribute to growth retardation.
BACKGROUND: The objective of the study is to assess the levels of tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) in patients with congenital heart diseases (CHDs) and control. PATIENTS AND METHODS: In this case-control study, sixty patients with CHD with ages of 1 month to 15 years and thirty healthy subjects were assessed. All objects measured in height, weight, age, sex, and body mass index (BMI). Patients diagnosed by echocardiography and patients' blood samples were 3 ml and taken in the catheterization laboratory through catheter and kept for 60 min at a room with normal temperature and separated serum has been held. All samples in compliance with the cold chain carried out to biochemistry laboratory and finally the levels of serum TNF-α and IL-6 were measured by Elisa Kit. Data were analyzed with Statistical Package for Social Sciences version 20. Nonparametric tests by considering 95% confidence interval were applied. RESULTS: The mean of age in cyanotic patients was 4.28 3.44 years, a cyanotic was 3.12 3.87 years and for the control group was 3.30 3.61 years. Comparison of TNF-α (Mann-Whitney U-test = 56.62, P < 0.001), IL-6 (Mann-Whitney U-test = 313.5, P < 0.001), right ventricular (RV) pressure (Mann-Whitney U-test = 27, P < 0.001), pulmonary artery (PA) pressure (Mann-Whitney U-test = 618, P = 0.015), and BMI (Mann-Whitney U-test = 214.5, P < 0.001) in the case and control groups resulted in significant differences. To compare TNF-α (Chi-square = 57.82, P < 0.001), IL-6 (Chi-square = 54.70, P < 0.001), RV pressure (Chi-square = 71.35, P < 0.001), PA pressure (Chi-square = 5.92, P = 00.052), oxygen saturation (Chi-square = 74.70, P < 0.001), and BMI (Chi-square = 34.90, P < 0.001) in cyanotic, acyanotic, and control groups resulted that there were significant differences between these three groups except PA pressure. CONCLUSION: The findings of this study showed that in patients with CHD, serum levels of TNF-α increased but IL-6 not changed when compared to control and this increase in necrosis tumoral factor-α would be related with hypoxia and remarkable left to right shunt and caused growth retardation in these patients.
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Teimouri et al. (2016) conducted a case-control in Congenital heart disease (n=90). Congenital heart disease vs. Healthy controls was evaluated on Serum level of TNF-α (p=<0.001). Congenital heart disease was associated with significantly elevated serum levels of TNF-α (mean 100.69 vs 24.09) and IL-6 compared to healthy controls (p<0.001).
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