Key result
Cardiopulmonary bypass in children with congenital heart disease was associated with significantly lower serum TNF-α levels 24 hours post-operation compared to off-pump surgery (P=.006).
Why the study?
Does cardiopulmonary bypass alter serum TNF-α levels compared to off-pump surgery in children with congenital heart disease?
Cohort (n=67)
Does cardiopulmonary bypass alter serum TNF-α levels compared to off-pump surgery in children with congenital heart disease?
Serum TNF-α levels show a transient and dramatic decline 24 hours after cardiopulmonary bypass in children with congenital heart disease, suggesting its potential as a biological indicator for monitoring CPB efficacy.
OBJECTIVE: To investigate the changes in tumor necrosis factor alpha (TNF-α) serum levels after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD), followed by a meta-analysis to analyze the clinical value of TNF-α in CPB. METHODS: Our cohort study enrolled 67 CHD children, assigned into off-pump group (n=32) and CPB group (n=35). The TNF-α serum levels in two groups were detected by ELISA before the operation (T1), at the end of the operation (0 hour, T2), and after 24 hours of the operation (T3). For meta-analysis, literature search was conducted to identify published case-control articles about the changes of TNF-α serum levels with CPB of CHD. RESULTS: The TNF-α levels in CPB group were lower than that in the off-pump group at T3 (P=.006). TNF-α level at T3 was significantly lower than that at T1 and T2 (all P<.05). Meta-analysis results further confirmed that the TNF-α levels of CHD children were dramatically decreased at T3 as compared to that at T1 and T2 (both P<.001). CONCLUSION: The TNF-α serum levels showed a transient and dramatic decline after 24 hours of CPB, and it may act as an important biological indicator for monitoring the efficacy of CPB in CHD children.
No takes yet. Share an insight, caveat, or question.
Song et al. (2016) conducted a cohort in congenital heart disease (n=67). Cardiopulmonary bypass (CPB) vs. Off-pump was evaluated on TNF-α serum levels at 24 hours after operation (T3) (p=.006). Cardiopulmonary bypass in children with congenital heart disease was associated with significantly lower serum TNF-α levels 24 hours post-operation compared to off-pump surgery (P=.006).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: