Key result
Cytokine measurements not corrected for haemodilution were significantly lower than corrected values in CABG patients, indicating haemodilution causes underestimation of cytokine release.
Why the study?
Does correction for haemodilution alter the measured perioperative serum concentrations of cytokines in patients undergoing CABG with CPB?
Population
20 male patients undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass and…
Comparison
Correction of cytokine measurements for… vs Cytokine measurements not corrected for…
Design
Cohort
Follow-up
up to the second post-operative day
Authors
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May warrant adjusted cytokine interpretation accounting for haemodilution; leaves open prognostic value in cardiac surgery.
Observational (n=20)
Does correction for haemodilution alter the measured perioperative serum concentrations of cytokines in patients undergoing CABG with CPB?
p-value: p=<0.01
Perioperative haemodilution significantly lowers measured cytokine levels, suggesting that correcting for haemodilution is necessary to avoid underestimating cytokine secretion during cardiac surgery.
Roth-Isigkeit et al. (1999) conducted an observational in Coronary artery bypass grafting (CABG) surgery (n=20). Correction for haemodilution vs. No correction for haemodilution was evaluated on Serum concentrations of TNF-alpha, IL-1beta, IL-6, IL-10 and sIL-2R (p=<0.01). Cytokine measurements not corrected for haemodilution were significantly lower than corrected values in CABG patients, indicating haemodilution causes underestimation of cytokine release.
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