Why the study?
How does cardiopulmonary bypass alter the cytokine network in patients undergoing elective coronary artery bypass grafting?
Population
24 patients undergoing elective coronary artery bypass grafting
Design
Cohort
Follow-up
up to 48 hours postoperatively
Authors
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Cytokine shifts after CPB may flag postoperative inflammatory risk; hypothesis-generating for immunomodulation trials in cardiac surgery.
How does cardiopulmonary bypass alter the cytokine network in patients undergoing elective coronary artery bypass grafting?
Cardiopulmonary bypass induces a distinct pattern of intraoperative immunosuppression followed by early postoperative immunological activation and an acute phase response.
Sablotzki et al. (1997) studied this question.
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