Key result
Rhubarb treatment significantly reduced blood glucose levels in animal models of diabetic nephropathy compared to control groups (SMD -1.09).
Why the study?
Multiple studies have applied rhubarb for diabetic nephropathy, but evaluating its efficacy, active ingredients, and specific mechanisms was needed to provide a scientific reference for clinical application.
Does rhubarb or its components improve renal and glycemic biomarkers in animal models of diabetic nephropathy?
Population
Animals with diabetic nephropathy across 27 eligible studies
Comparison
Rhubarb or its extracted components vs control
Design
Systematic review and meta-analysis of animal studies
Authors
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Rhubarb improves multiple renal and metabolic markers in animal DN models; leaves open translation to human efficacy and safety, warranting clinical trials.
Meta-Analysis (n=731)
Does rhubarb or its components improve renal and glycemic biomarkers in animal models of diabetic nephropathy?
Standardized Mean Difference: -1.09 (95% CI -1.45–-0.73)
p-value: p=<0.00001
In animal models of diabetic nephropathy, rhubarb and its components significantly improved glycemic control and renal function biomarkers, providing a theoretical basis for clinical application.
Zeng et al. (2021) conducted a meta-analysis in Diabetic nephropathy (n=731). Rhubarb (including rhein and emodin) vs. Vehicle, sham, or no treatment was evaluated on Blood glucose (SMD -1.09, 95% CI -1.45 to -0.73, p=<0.00001). Rhubarb treatment significantly reduced blood glucose levels in animal models of diabetic nephropathy compared to control groups (SMD -1.09).
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