Key result
Biaxial testing of healthy porcine myocardium demonstrated that the right ventricle, left ventricle, and mid-wall exhibit non-linear, heterogeneous, anisotropic, and slightly different mechanical properties.
Why the study?
Heart myocardium mechanical properties were previously assumed homogeneous, but regional mechanics are vital for developing accurate computational models to guide therapies.
This study demonstrates that healthy porcine myocardium exhibits non-linear, heterogeneous, and anisotropic mechanical properties that vary by region, providing essential data for developing accurate computational models of the heart.
Regional mechanics modeling may advance cardiac therapies; level 5 evidence leaves open clinical translation for MI in high-burden regions.
Regional mechanics of the heart is vital in the development of accurate computational models for the pursuit of relevant therapies. Challenges related to heart dysfunctioning are the most important sources of mortality in the world. For example, myocardial infarction (MI) is the foremost killer in sub-Saharan African countries. Mechanical characterisation plays an important role in achieving accurate material behaviour. Material behaviour and constitutive modelling are essential for accurate development of computational models. In most cases previously, the mechanical properties of the heart myocardium were assumed to be homogeneous. The main objective of this paper is to determine the mechanical material properties of healthy porcine myocardium in three regions, namely left ventricle (LV), mid-wall/interventricular septum (MDW) and right ventricle (RV). The biomechanical properties of the pig heart RV, LV and MDW were characterised using biaxial testing. The biaxial tests show the pig heart myocardium behaves non-linearly, heterogeneously and anisotropically. In this study, it was shown that RV, LV and MDW may exhibit slightly different mechanical properties. Data presented here may be helpful in regional tissue mechanics, especially for the understanding of various heart diseases and development of new therapies.
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Fulufhelo Ṋemavhola (2020) studied Healthy porcine myocardium. Biaxial testing of regional myocardium was evaluated on Mechanical material properties. Biaxial testing of healthy porcine myocardium demonstrated that the right ventricle, left ventricle, and mid-wall exhibit non-linear, heterogeneous, anisotropic, and slightly different mechanical properties.
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