Syntheses of Macrocyclic Lactones by Ring Enlargement Reaction A general method is given for the synthesis of macrocyclic lactones by ring enlargement of 2‐nitrocycloalkanones by four ring members. By this procedure 2‐nitrocyclooctanone (1) is transformed to 8‐oxo‐dodecan‐11‐olid (5) in an overall yield of 63,5% and 2‐nitrocyclododecanone to 12‐oxo‐hexadecan‐15‐olid with 60% yield.
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Kostova et al. (1983) studied this question.
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