Key result
Radiotherapy for soft tissue sarcomas in the arms and legs enables extremity-preserving treatment in over 90% of patients, with pre- and postoperative radiotherapy demonstrating similar efficacy.
Why the study?
Does radiotherapy combined with surgery improve outcomes and preserve extremities in patients with soft tissue sarcomas?
Population
3,444 patients with soft tissue sarcomas from 71 scientific articles
Comparison
Radiotherapy combined with surgery vs Surgery alone or different radiotherapy regimens
Design
Review
Authors
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Supports limb preservation with radiotherapy in extremity sarcomas; leaves open optimal timing and adjunctive therapies in prospective trials.
Systematic Review (n=3,444)
Does radiotherapy combined with surgery improve outcomes and preserve extremities in patients with soft tissue sarcomas?
Radiotherapy combined with surgery allows for extremity preservation in over 90% of patients with soft tissue sarcomas in the arms and legs, though combining it with intraarterial chemotherapy increases complication risks.
Thor Alvegård (1996) conducted a systematic review in Soft tissue sarcomas (n=3,444). Radiotherapy was evaluated. Radiotherapy for soft tissue sarcomas in the arms and legs enables extremity-preserving treatment in over 90% of patients, with pre- and postoperative radiotherapy demonstrating similar efficacy.
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