Key result
Remifentanil infusion significantly shortened induction times to loss of eyelash reflex compared to fentanyl when used with propofol (50.7s vs 74.9s, P<0.01), thiopental, or etomidate.
Why the study?
Does remifentanil compared to fentanyl improve anaesthetic induction characteristics of propofol, thiopental, or etomidate in patients undergoing anaesthesia?
RCT (n=72)
Double-blind
randomized
Does remifentanil compared to fentanyl improve anaesthetic induction characteristics of propofol, thiopental, or etomidate in patients undergoing anaesthesia?
Absolute Event Rate: 50.7% vs 74.9%
p-value: p=<0.01
Remifentanil infusion is a suitable alternative to fentanyl bolus for anaesthetic induction, resulting in shorter induction times and reduced requirements for propofol, thiopental, or etomidate.
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Favors remifentanil infusion for faster routine induction; extends RCT evidence across propofol, thiopental, and etomidate.
Wilhelm et al. (2002) conducted an RCT in Anaesthetic induction (n=72). Remifentanil vs. Fentanyl was evaluated on Induction time to loss of eyelash reflex with propofol (seconds) (p=<0.01). Remifentanil infusion significantly shortened induction times to loss of eyelash reflex compared to fentanyl when used with propofol (50.7s vs 74.9s, P<0.01), thiopental, or etomidate.
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