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Advances in genetics and molecular biology have led to a better understanding of the control of central nervous system (CNS) development. It is possible to classify CNS abnormalities according to the developmental stages at which they occur, as is shown below. The careful assessment of patients with these abnormalities is important in order to provide an accurate prognosis and genetic counselling. Before we review the various abnormalities that can affect the CNS, a brief overview of the normal development of the CNS is appropriate.
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Christopher Verity (2003) studied this question.
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