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The new cyclopropyl carbocyclic nucleosides 1 and 2 have been synthesized by following short and efficient routes starting from conveniently protected (−)-( Z )-methanohomoserine derivative 3 . Both products 1 and 2 bear a quaternary stereogenic center and have opposite chirality. Moreover, the adenine derivative 2 belongs to a new class of cyclopropyl nucleoside showing an amino alcohol function at C-1 in addition to a methylene spacer between the base and the carbocyclic ring.
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Rifé et al. (1999) studied this question.
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